Toward Brain Computer Interfacing: Algorithms for on-line Differentiation of Neuroelectric Activities Prof Dr. Klaus-Robert Mueller(1-3) (1) Technical University of Berlin, Computer Science, Berlin (2) Bernstein Zentrum for Computational Neuroscience Berlin (3) Bernstein Focus for Neurotechnology Berlin Brain Computer Interfacing (BCI) aims at making use of brain signals for e.g. the control of objects, spelling, gaming and so on. This talk will first provide a brief overview of Brain Computer Interface from a machine learning and signal processing perspective. In particular it shows the wealth, the complexity and the difficulties of the data available, a truely enormous challenge: In real-time a multi-variate very strongly noise contaminated data stream is to be processed and neuroelectric activities are to be accurately differentiated in real time. Finally, I report in more detail about the Berlin Brain Computer (BBCI) Interface that is based on EEG signals and take the audience all the way from the measured signal, the preprocessing and filtering, the classification to the respective application.  BCI as a new channel for man-machine communication is discussed in a clincial setting and for gaming. This is joint work with Benjamin Blankertz, Michael Tangermann, Claudia Sanelli, Carmen Vidaurre, Thorsten Dickhaus (TU Berlin), Steven Lemm, Guido Nolte, Andreas Ziehe, Florin Popescu (Fraunhofer FIRST, Berlin) Gabriel Curio, Vadim Nikulin (Charite, Berlin) and further member of the Berlin Brain Computer Interface team, see www.bbci.de. short CV Klaus-Robert Müller has been Professor for Computer Science at TU Berlin since 2006; at the same time he is directing the Bernstein Focus on Neurotechnology Berlin. He studied physics in Karlsruhe from 1984-89 and also obtained his PhD in Computer Science at TU Karlsruhe in 1992. After a PostDoc at GMD FIRST in Berlin from 1992-1994, he was a European Community STP Research Fellow at University of Tokyo from 1994-1995. From 1995 he built up the Intelligent Data Analysis (IDA) group at GMD FIRST (later Fraunhofer FIRST) and and directed it until 2008. 1999-2006 he was a Professor for Computer Science at University of Potsdam.  In 1999, he was awarded the Olympus Prize by the German Pattern Recognition Society, DAGM and in 2006 he received the SEL Alcatel Communication Award. His research interests are intelligent data analysis, machine learning, statistical signal processing and statistical learning theory with the application foci computational finance, computational chemistry, computational neuroscience and genomic data analysis. Since 2000 one of his main scientific interests is to study the interface between brain and machine: non-invasive EEG-based Brain Computer Interfacing.